Ocular Neuroprotection
edited byLeonard A. LevinUniversity of Wisconsin-MadisonMadison, Wisconsin, U.S. A.Adriana Di PoloUniversity of MontrealMontreal, Quebec, Canada
MARCEL D E K K E RNEW YORK - BASEL
Neuroprotection comprises a broad range of therapeutic strategies aimed at preventingdeath of neurons in trauma or disease. As applied to ocular disorders,neuroprotection has received enormous attention in past years because of its potentialfor treating diseases that were heretofore untreatable or difficult to treat,including disorders primarily involving death of photoreceptors (such as in maculardegeneration, retinitis pigmentosa, and retinal detachment) or retinal ganglioncells (such as in glaucoma).The goal of this book is to provide the reader with up-to-date ocular neuroprotectionresearch methods that are used in leading laboratories worldwide.Chapters 1 through 15 focus on research methods at the laboratory level, withemphasis on various cell culture and animal models, classes of neuroprotectivedrugs, biochemical and cellular outcome measures, and applicability to humandisease. Chapters 16 through 18 focus on how clinical trials of neuroprotectionmay be carried out, concentrating on issues of recruitment, outcome measures,and requirements of regulatory agencies.The information conveyed in this book is intended to be practical. Thechapters address the nuts and bolts of the actual methods themselves, along withpotential problems, solutions to those problems, potential shortcuts (and contraindicationsto shortcuts), and specific suppliers, where appropriate. The book isnot intended to be an exhaustive presentation of research data or theories, butrather to provide a focused description of useful methods for conducting neuroprotectionresearch.This book will acquaint those considering research in the area with themajor techniques, tools, and issues in ocular neuroprotection, while investigatorswith experience in neuroprotection research may benefit from exposure to newmodels, methodologies, and clinical approaches. Regardless of the reader’s experience,this volume will be an invaluable resourceWe sincerely thank all the contributors—leading scientists in their fields—who have generously shared their knowledge and expertise in each chapter. فهرست کتاب در فایل دمو موجود است.

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:: برچسب‌ها: پزشکی , چشم , عصب شناسی , کتاب , marcel dekker , Ocular Neuroprotection , NEW YORK , Leonard A , Levin , Adriana Di Polo ,
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